Department of Periodontics, University of Maryland, School of Dentistry, Baltimore, MD 21201, USA.
J Evid Based Dent Pract. 2012 Sep;12(3 Suppl):118-26. doi: 10.1016/S1532-3382(12)70023-4.
Protein and peptide-based therapeutics provide a unique strategy for controlling highly specific and complex biologic actions that cannot be accomplished by simple devices or chemical compounds. This article reviews some of the key characteristics and summarizes the clinical effectiveness of protein and peptide-based therapeutics targeting periodontal regeneration.
A literature search was conducted of randomized clinical trials and systematic reviews evaluating protein and peptide-based therapeutics for the regeneration of periodontal tissues of at least 6 months duration. Data sources included PubMed and Embase electronic databases, hand-searched journals, and the ClinicalTrials.gov registry.
Commercially marketed protein and peptide-based therapeutics for periodontal regeneration provide gains in clinical attachment level and bone formation that are comparable or superior to other regenerative approaches. Results from several clinical trials indicate that protein and peptide-based therapies can accelerate repair and regeneration when compared with other treatments and that improvements in clinical parameters continue beyond 12 months. Protein and peptide-based therapies also exhibit the capacity to increase the predictability of treatment outcomes.
Clinical and histologic studies support the effectiveness of protein- and peptide-based therapeutics for periodontal regeneration. Emerging evidence suggests that the delivery devices/scaffolds play a critical role in determining the effectiveness of this class of therapeutics.
蛋白质和肽类治疗剂为控制高度特异性和复杂的生物作用提供了独特的策略，这些作用是简单的设备或化合物无法完成的。本文综述了一些关键特征，并总结了针对牙周再生的蛋白质和肽类治疗剂的临床效果。
对至少持续 6 个月的蛋白质和肽类治疗牙周组织再生的随机临床试验和系统评价进行了文献检索。数据来源包括 PubMed 和 Embase 电子数据库、手工检索的期刊以及 ClinicalTrials.gov 注册处。
商业化的蛋白质和肽类治疗牙周再生的治疗剂在临床附着水平和骨形成方面提供的收益与其他再生方法相当或更优。几项临床试验的结果表明，与其他治疗方法相比，蛋白质和肽类治疗剂可以加速修复和再生，并且在 12 个月后临床参数仍在改善。蛋白质和肽类治疗剂还具有提高治疗效果可预测性的能力。
临床和组织学研究支持蛋白质和肽类治疗剂在牙周再生中的有效性。新出现的证据表明，输送装置/支架在确定此类治疗剂的有效性方面起着关键作用。
