Selman S H, Qin B S, James H R, Keck R W, Garbo G M, Morgan A R
Department of Surgery (Urology), Medical College of Ohio, Toledo 43699.
J Urol. 1990 Mar;143(3):630-3. doi: 10.1016/s0022-5347(17)40044-9.
Changes in blood flow to transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide induced bladder tumors growing subcutaneously in the flanks of Fischer CDF (F344/CrlBR) rats were measured after photodynamic therapy with the photosensitizer tin (II) etiopurpurin dichloride using the radioactive microsphere technique. As with the other photosensitizers, hematoporphyrin derivative and chloroaluminum tetrasulfophtalocyanine, tin (II) etiopurpurin dichloride and light caused a rapid decrease in tumor blood flow in this tumor model. The decrease in blood flow occurred whether the vehicle for photosensitizer delivery was an emulsion or a liposome. Systemic heparinization of animals prior to light treatment did not alter changes in tumor blood flow.
采用放射性微球技术，在用二氯化锡（II）叶卟吩紫作为光敏剂进行光动力治疗后，测量了移植于Fischer CDF（F344/CrlBR）大鼠胁腹皮下生长的可移植性N-[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺诱导膀胱肿瘤的血流变化。与其他光敏剂血卟啉衍生物和四磺基铝酞菁氯一样，二氯化锡（II）叶卟吩紫和光照导致该肿瘤模型中的肿瘤血流迅速减少。无论光敏剂递送载体是乳剂还是脂质体，血流都会减少。在光照治疗前对动物进行全身肝素化处理，并未改变肿瘤血流的变化。
