Department of Hematology and Oncology, St. Luke's Roosevelt Hospital Center, New York, New York 10019, USA.
Semin Thromb Hemost. 2012 Nov;38(8):780-2. doi: 10.1055/s-0032-1328889. Epub 2012 Oct 6.
The syndrome of cocaine-levamisole thrombotic vasculopathy is a tetrad of cutaneous manifestations, arthralgia, leukopenia, and positive antineutrophil cytoplasmic antigen (ANCA). Cocaine is cut with levamisole to potentiate its euphoric effects. However, along with this are the adverse reactions of levamisole such as fatal agranulocytosis, flu-like symptoms, and cutaneous thrombotic vasculopathy. High index of suspicion is needed for its diagnosis. This article will review on its toxicities, especially its prothrombotic effects.
可卡因-左旋咪唑血栓性血管病综合征是一组皮肤表现、关节痛、白细胞减少和抗中性粒细胞胞质抗体（ANCA）阳性。可卡因与左旋咪唑混合使用可增强其欣快感。然而，随之而来的是左旋咪唑的不良反应，如致命性粒细胞缺乏症、流感样症状和皮肤血栓性血管病。需要高度怀疑其诊断。本文将综述其毒性，特别是其促血栓形成作用。
