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在蛋白质的定点修饰上实现魏悌希反应。

Enabling Wittig reaction on site-specific protein modification.

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China.

出版信息

Chem Commun (Camb). 2012 Nov 21;48(90):11079-81. doi: 10.1039/c2cc35738k. Epub 2012 Oct 5.

DOI:10.1039/c2cc35738k
PMID:23042100
Abstract

An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag" was presented. A variety of functional groups could be introduced into the protein of interest.

摘要

首次在蛋白质生物偶联中实现了高效的水相 Wittig 反应。通过对小分子、肽和蛋白质的反应进行研究，提出了一种针对“醛标签”的定点反应。可以将各种官能团引入到感兴趣的蛋白质中。

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