蛋白质谷胱甘肽化概述。
Overview of protein glutathionylation.
作者信息
Filipovska Aleksandra, Murphy Michael P
机构信息
Medical Research Council, Dunn Human Nutrition Unit, Cambridge, United Kingdom.
出版信息
Curr Protoc Toxicol. 2006 Jun;Chapter 6:Unit6.10. doi: 10.1002/0471140856.tx0610s28.
PMID:23045136
Abstract
Many proteins contain free thiols that can be modified by the reversible formation of mixed disulfides with glutathione. Protein glutathionylation is of significance for defense against oxidative damage and in redox signaling. Here we outline the mechanisms and possible significance of protein glutathionylation.
摘要
许多蛋白质含有游离巯基，这些游离巯基可通过与谷胱甘肽可逆形成混合二硫键而被修饰。蛋白质谷胱甘肽化对于抵御氧化损伤和氧化还原信号传导具有重要意义。在此，我们概述了蛋白质谷胱甘肽化的机制及其可能的意义。
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