Young Kymberly D, Erickson Kristine, Drevets Wayne C
National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland, USA.
Psychol Rep. 2012 Aug;111(1):129-48. doi: 10.2466/09.02.15.PR0.111.4.129-148.
Major depressive disorder (MDD) is associated with deficits in recalling specific autobiographical memories. The current study goal was to assess whether emotionally valenced cue words led to memories of similar emotional valence and whether this pattern differed between 12 unmedicated MDD and 14 healthy control participants. Both groups recalled autobiographical memories in response to positive, negative, and neutral cue words. Positive and neutral cues prompted recall of positive memories less often in the MDD group than in the controls. MDD participants recalled fewer specific and more categorical memories than controls; however, the proportion of specific memories didn't differ across memory valences. The MDD group had fewer specific memories in response to positive and neutral cues than the controls. These results suggest that the MDD participants may process positive stimuli differently than healthy controls and that their recall of specific autobiographical memories is impaired, regardless of the affective valence of those memories.
重度抑郁症（MDD）与特定自传体记忆的回忆缺陷有关。当前的研究目标是评估情绪效价线索词是否会引发具有相似情绪效价的记忆，以及这种模式在12名未服药的MDD患者和14名健康对照参与者之间是否存在差异。两组参与者都根据积极、消极和中性线索词回忆自传体记忆。与对照组相比，MDD组对积极和中性线索词的反应中，较少引发积极记忆。MDD参与者回忆起的具体记忆比对照组少，分类记忆比对照组多；然而，具体记忆的比例在不同情绪效价的记忆中并无差异。与对照组相比，MDD组对积极和中性线索词的反应中，具体记忆较少。这些结果表明，MDD参与者对积极刺激的处理方式可能与健康对照者不同，并且他们对特定自传体记忆的回忆受损，无论这些记忆的情感效价如何。
