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[心脏手术后的认知功能障碍]

[Cognitive dysfunction after cardiac surgery].

作者信息

Szwed Krzysztof, Bieliński Maciej, Drozdz Wiktor, Pawliszak Wojciech, Hoffmann Andrzej, Anisimowicz Lech, Borkowska Alina

机构信息

Katedra i Zakład Neuropsychologii Klinicznej Collegium Medicum UMK w Bydgoszczy.

出版信息

Psychiatr Pol. 2012 May-Jun;46(3):473-82.

Abstract

In spite of the progress in medicine post operative cognitive deficiency (POCD) remains an important clinical problem. Since the introduction of cardiac surgery there have been frequent reports of its adverse neurological outcomes. Recent technological advances have contributed to a lesser occurrence of clinically evident complications such as coma, stroke, epilepsy or blindness. This brought to attention a more common yet occult disorder--POCD. The above malady mostly concerns memory and executive functions. POCD has a negative impact on the quality of life and labor market attachment, however it's relation to mortality seems to be most disturbing. Prevalence of POCD is mainly associated with microembolisms, hipoperfusion and inflammatory reaction of the central nervous system following cardiac surgery. In addition many studies have shown the importance ofbiochemical disorders, cerebral oedema and the influence of comorbidities in the development of POCD. In the light of available evidence, there is no substantial difference between the cognitive outcomes of various types of cardiac surgery. Recent studies show that POCD in this clinical setting is mostly mild and transient. There are, however, patients who suffer from persisting POCD. Modern medicine has not developed standards for treatment of this complication. Setting up methods for prevention, detection and treatment of POCD should be the concern of both physicians and researchers in the following years.

摘要

尽管医学取得了进步,但术后认知功能障碍(POCD)仍然是一个重要的临床问题。自从心脏手术问世以来,关于其不良神经学后果的报道屡见不鲜。最近的技术进步使得诸如昏迷、中风、癫痫或失明等临床上明显的并发症发生率降低。这引起了人们对一种更常见但隐匿的疾病——POCD的关注。上述疾病主要涉及记忆和执行功能。POCD对生活质量和劳动力市场参与度有负面影响,然而它与死亡率的关系似乎最令人不安。POCD的患病率主要与心脏手术后的微栓塞、低灌注和中枢神经系统的炎症反应有关。此外,许多研究表明生化紊乱、脑水肿以及合并症在POCD发生发展中的重要性。根据现有证据,各种类型心脏手术的认知结果没有实质性差异。最近的研究表明,在这种临床情况下,POCD大多是轻度和短暂的。然而,也有患者患有持续性POCD。现代医学尚未制定出治疗这种并发症的标准。在接下来的几年里,建立POCD的预防、检测和治疗方法应该是医生和研究人员共同关注的问题。

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