Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
Ann N Y Acad Sci. 2012 Oct;1269:69-73. doi: 10.1111/j.1749-6632.2012.06694.x.
Thymosin β4 (Tβ4) has been found to have several biological activities related to antiscarring and reduced fibrosis. For example, the anti-inflammatory properties of Tβ4 and its splice variant have been shown in the eye and skin. Moreover, Tβ4 treatment prevents profibrotic gene expression in cardiac and in hepatic cells in vitro and in vivo. In a recent study on scleroderma patients it was hypothesized that Tβ4 may exert a protective effect during human lung injury. In an ongoing study, we have explored the putative Tβ4 protective role in the lung context by utilizing a well-known in vivo model. We have observed significant protective effects of Tβ4 on bleomycin-induced lung damage, the main outcomes being the halting of the inflammatory process and a substantial reduction of histological evidence of lung injury.
胸腺素 β4（Tβ4）具有多种与抗瘢痕和减少纤维化相关的生物学活性。例如，Tβ4 及其剪接变体在眼睛和皮肤中具有抗炎特性。此外，Tβ4 治疗可预防心脏和肝脏细胞中的致纤维化基因表达，无论是在体外还是在体内。在最近一项关于硬皮病患者的研究中，有人假设 Tβ4 可能在人类肺损伤期间发挥保护作用。在一项正在进行的研究中，我们通过利用一种众所周知的体内模型，探讨了 Tβ4 在肺部环境中的潜在保护作用。我们观察到 Tβ4 对博来霉素诱导的肺损伤具有显著的保护作用，主要结果是停止了炎症过程，并大大减少了肺损伤的组织学证据。
