Dante Pazzanese Institute of Cardiology, Department of Nutrition, São Paulo, Brazil.
J Ren Nutr. 2013 Jul;23(4):283-7. doi: 10.1053/j.jrn.2012.08.004. Epub 2012 Oct 6.
The malnutrition-inflammation score (MIS) is a nutritional scoring system that has been associated with muscle strength among dialysis patients. We aimed to test whether MIS is able to predict muscle strength in nondialysis-dependent chronic kidney disease (NDD-CKD) individuals.
This was a cross-sectional study conducted at the Dante Pazzanese Institute of Cardiology, Hypertension, and Nephrology Division outpatient clinic. We evaluated 190 patients with NDD-CKD stages 2-5 (median 59.5 [interquartile range 51.4-66.9] years; 64% men). MIS was calculated without computing dialysis vintage to the scoring. HGS was assessed in the dominant arm. Anthropometric, laboratory, and body composition parameters were recorded.
A strong negative correlation was found between HGS and MIS (r = -0.42; P ≤ .001) in univariate analysis. In multivariate regressions, adjustment for age, sex, diabetes, glomerular filtration rate, body cell mass, and C-reactive protein did not materially diminish these relationships.
MIS shares strong links with objective measures of muscle strength in NDD-CKD patients.
营养不良-炎症评分（MIS）是一种与透析患者肌肉力量相关的营养评分系统。我们旨在检验 MIS 是否能够预测非透析依赖型慢性肾脏病（NDD-CKD）个体的肌肉力量。
这是在但丁·帕赞泽内科心脏病学、高血压和肾脏病科门诊进行的一项横断面研究。我们评估了 190 名 NDD-CKD 2-5 期患者（中位年龄 59.5[四分位距 51.4-66.9]岁；64%为男性）。MIS 是在不计算到评分的透析龄的情况下计算的。使用优势手臂评估 HGS。记录了人体测量学、实验室和身体成分参数。
在单变量分析中，HGS 与 MIS 之间存在强烈的负相关（r = -0.42；P ≤.001）。在多变量回归中，调整年龄、性别、糖尿病、肾小球滤过率、细胞内液量和 C 反应蛋白后，这些关系并没有实质性的改变。
MIS 与 NDD-CKD 患者肌肉力量的客观测量指标密切相关。
