Hunan Key Laboratory of Pharmacogenetics, Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, People's Republic of China.
Pharmacogenet Genomics. 2012 Nov;22(11):812-9. doi: 10.1097/FPC.0b013e328358d92b.
The redox reaction of cytochrome P450 enzymes (CYP) is an important physiological and biochemical reaction in the human body, as it is involved in the oxidative metabolism of both endogenous and exogenous substrates. Cytochrome P450 oxidoreductase (POR) is the only obligate electron donor for all of the hepatic microsomal CYP enzymes. It plays a crucial role in drug metabolism and treatment by not only acting as an electron donor involved in drug metabolism mediated by CYP enzymes but also by directly inducing the transformation of some antitumor precursors. Studies have found that the gene encoding human POR is highly polymorphic, which is of considerable clinical significance as it affects the metabolism and curative effects of clinically used drugs. This review aims to discuss the effect of POR and its genetic polymorphisms on drug metabolism and therapy, as well as the potential mechanisms of POR pharmacogenetics.
细胞色素 P450 酶（CYP）的氧化还原反应是人体内重要的生理和生化反应，因为它涉及内源性和外源性底物的氧化代谢。细胞色素 P450 氧化还原酶（POR）是所有肝微粒体 CYP 酶的唯一必需电子供体。它在药物代谢和治疗中起着至关重要的作用，不仅作为涉及 CYP 酶介导的药物代谢的电子供体，而且还直接诱导一些抗肿瘤前体的转化。研究发现，编码人 POR 的基因高度多态性，这具有重要的临床意义，因为它影响临床使用药物的代谢和疗效。本综述旨在讨论 POR 及其遗传多态性对药物代谢和治疗的影响，以及 POR 药物遗传学的潜在机制。
