Department of Biomolecular Sciences, University of Urbino, Piazza Rinascimento 6, 61029 Urbino (PU), Italy.
Org Biomol Chem. 2012 Nov 28;10(44):8860-7. doi: 10.1039/c2ob26516h.
A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.
已经通过晚期多样化 8-溴-9-去氮杂嘌呤来制备了一个 8-取代的 9-去氮杂嘌呤的小文库。通过利用钯催化的交叉偶联反应，一个单一的关键前体可以转化为多种 8-取代的 9-去氮杂嘌呤化合物。三个关键的 8-溴-9-去氮杂嘌呤中间体可以通过商业上可获得的 6-氯尿嘧啶在六步反应中高效制备。
