Yasar Sirin, Gurleyik Gunay, Sabuncuoglu Yesim, Aktekin Ali, Yasar Bulent, Serdar Zehra A
Department of Dermatology, Haydarpaşa Numune Teaching and Research Hospital, 34668 Istanbul, Turkey.
Case Rep Med. 2012;2012:515691. doi: 10.1155/2012/515691. Epub 2012 Sep 19.
Amyopathic dermatomyositis (AD) can be a part of paraneoplastic syndrome of an underlying malignancy. Paget's disease is a rare form of breast cancer. We present a very rare case of Paget's disease associated with AD. Paget's disease has been diagnosed in a patient with AD who is under surveillance of dermatology department. The patient has undergone central lumpectomy with removal of the nipple-areola complex and sentinel lymph node biopsy. Surgical margins after lumpectomy and sentinel node biopsy were negative. The whole breast irradiation was performed after surgery. The patient receives medical treatment for AD of which lesions regressed in 1 year during the follow-up period. This is a very rare case of Paget's disease diagnosed in a patient with AD. Female patients with dermatomyositis have been absolutely recommended to undergo screening for breast and gynaecological malignancies. AD may be an early finding of primary or recurrent malignancy of the breast.
无肌病性皮肌炎（AD）可能是潜在恶性肿瘤副肿瘤综合征的一部分。佩吉特病是一种罕见的乳腺癌形式。我们报告一例极为罕见的与AD相关的佩吉特病病例。一名正在皮肤科接受监测的AD患者被诊断出患有佩吉特病。该患者接受了保留乳头乳晕复合体的中央肿块切除术和前哨淋巴结活检。肿块切除术后及前哨淋巴结活检的手术切缘均为阴性。术后进行了全乳照射。患者接受了AD的药物治疗，随访期间病变在1年内消退。这是在AD患者中诊断出佩吉特病的极为罕见的病例。绝对建议皮肌炎女性患者接受乳腺癌和妇科恶性肿瘤筛查。AD可能是乳腺原发性或复发性恶性肿瘤的早期表现。
