山东省临沂市农村婴幼儿血清视黄醇和类胡萝卜素及其相关饮食影响因素分析

[Serum retinol and carotenoid of rural infants and young children in Linyi of Shangdong Province and analysis on their related influencing dietary factors].

作者信息

Fan Ping, Shen Yao, Li Yonghua, Ma Aiqin, Sun Zhongqing, Wang Zhixu

机构信息

Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China.

出版信息

Wei Sheng Yan Jiu. 2012 May;41(3):424-8.

PMID:23050441

Abstract

OBJECTIVE

The study was carried out to determine serum retinol and carotenoid of infants and young children in rural areas, and to explore their related dietary factors.

METHODS

A total of 254 rural healthy infants and young children aged 6-24 month-old were recruited from a program for health examination and feeding survey conducted in villages in Meibu of Linyi of Shandong Province by cluster sampling method. Serum retinol, beta-carotene, alpha-carotene, beta-cryptoxanthin and lutein + zeaxanthin were detected with HPLC. The frequency of food intake of babies during the past month was inquired from their mothers or baby-sitters. The relationship between serum retinol and carotenoid level with some factors related to feeding pattern was analyzed.

RESULTS

The average serum retinol was (0.96 +/- 0.55) micromol/L with little variation by age (P > 0.05). The prevalence of serum vitamin A deficiency and marginal deficiency were 40.6% and 32.6%. The average serum beta-carotene, alpha-carotene, beta-cryptoxanthin and lutein + zeaxanthin were (0.056 +/- 0.088) micromol/L, (3.3 +/- 12.1) nmol/L, (27.0 +/- 45.2) nmol/L and (0.22 +/- 0.22) micromol/L, respectively, and no significant difference between age groups on serum beta-carotene, alpha-carotene and beta-cryptoxanthin (all were P > 0.05) except lutein + zeaxanthin (P < 0.05). Breast feeding and formula feeding were significant dietary factors influencing serum retinol and carotenoids levels. The frequency of breast-feeding was correlated significantly with serum beta-carotene (P < 0.05). Serum retinol was correlated positively with carotenoids and among carotenoids with each other (all were P < 0.001).

CONCLUSION

Vitamin A deficiency and marginal deficiency were prevalent in the investigated infants and young children. Serum carotenoid was little variation with age, but was different significantly with dietary patterns fed by breast milk, formula, or fruits and vegetables.

摘要

目的

本研究旨在测定农村地区婴幼儿血清视黄醇和类胡萝卜素水平，并探讨其相关饮食因素。

方法

采用整群抽样方法，从山东省临沂市郯城县某村庄进行的健康检查和喂养调查项目中，招募了254名6至24月龄的农村健康婴幼儿。采用高效液相色谱法检测血清视黄醇、β-胡萝卜素、α-胡萝卜素、β-隐黄质和叶黄素+玉米黄质。通过询问其母亲或保姆，了解婴儿过去一个月的食物摄入频率。分析血清视黄醇和类胡萝卜素水平与一些喂养模式相关因素之间的关系。

结果

血清视黄醇平均水平为（0.96±0.55）μmol/L，各年龄组间差异无统计学意义（P>0.05）。血清维生素A缺乏率和边缘缺乏率分别为40.6%和32.6%。血清β-胡萝卜素、α-胡萝卜素、β-隐黄质和叶黄素+玉米黄质的平均水平分别为（0.056±0.088）μmol/L、（3.3±12.1）nmol/L、（27.0±45.2）nmol/L和（0.22±0.22）μmol/L，除叶黄素+玉米黄质外（P<0.05），各年龄组间血清β-胡萝卜素、α-胡萝卜素和β-隐黄质差异均无统计学意义（均为P>0.05）。母乳喂养和配方奶喂养是影响血清视黄醇和类胡萝卜素水平的重要饮食因素。母乳喂养频率与血清β-胡萝卜素显著相关（P<0.05）。血清视黄醇与类胡萝卜素呈正相关，类胡萝卜素之间也呈正相关（均为P<0.001）。