Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, 120-752, South Korea.
Calcif Tissue Int. 2012 Dec;91(6):370-8. doi: 10.1007/s00223-012-9642-1. Epub 2012 Sep 29.
The aim of this study was to investigate the relationship between aortic calcification (AC) and low bone mineral density (BMD), 25(OH)D, C-terminal telopeptide (CTx), and osteocalcin levels in Asian women. We also tried to find the association between AC and the risk of vertebral fracture. We included 769 patients in this study. All patients underwent QCT. Aortic calcium score (ACS) was quantified by the Agatston scoring method. Spinal fracture was defined by lumbar spine radiography. Among 769 subjects, 96 had at least one vertebral fracture and 345 had AC. ACS positively correlated with age. Osteocalcin, CTx, 25(OH)D, total-hip trabecular BMD (tBMD), femoral neck tBMD, and vertebral tBMD were inversely related with ACS. However, cortical BMD (cBMD) did not correlate with ACS. Among these parameters, only osteocalcin significantly correlated with ACS, even after adjusting for age. We divided the subjects into two groups based on the presence of AC to determine the association between AC and vertebral fracture. Multivariate logistic regression analysis showed that age, tBMD of each site, and AC were associated with vertebral fractures. After adjusting for confounding factors, patients with AC had more than a threefold increased risk of vertebral fracture (OR = 3.29-3.57, P < 0.05 according to site). This study suggests that high ACS is related to low tBMD but not cBMD. Furthermore, our findings indicate that this relationship is definitely age-dependent. Finally, we found that AC is significantly associated with the prevalence of vertebral fracture in Asian women.
本研究旨在探讨亚洲女性主动脉钙化（AC）与低骨密度（BMD）、25（OH）D、C 端肽（CTx）和骨钙素水平之间的关系。我们还试图寻找 AC 与椎体骨折风险之间的关联。我们纳入了 769 名患者进行研究。所有患者均接受 QCT 检查。采用 Agatston 评分法对主动脉钙评分（ACS）进行定量。通过腰椎 X 线摄影定义脊柱骨折。在 769 例患者中，96 例至少有 1 例椎体骨折，345 例有 AC。ACS 与年龄呈正相关。骨钙素、CTX、25（OH）D、全髋小梁骨密度（tBMD）、股骨颈 tBMD 和椎体 tBMD 与 ACS 呈负相关。然而，皮质骨密度（cBMD）与 ACS 无关。在这些参数中，只有骨钙素与 ACS 显著相关，即使在调整了年龄后也是如此。我们根据是否存在 AC 将患者分为两组，以确定 AC 与椎体骨折之间的关系。多变量逻辑回归分析表明，年龄、各部位 tBMD 和 AC 与椎体骨折有关。在调整混杂因素后，AC 患者椎体骨折的风险增加了三倍以上（根据部位，OR=3.29-3.57，P<0.05）。本研究表明，高 ACS 与低 tBMD 相关，但与 cBMD 无关。此外，我们的研究结果表明，这种关系肯定是年龄依赖性的。最后，我们发现 AC 与亚洲女性椎体骨折的患病率显著相关。
