Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, via Olgettina 60, 20132 Milan, Italy.
J Neurol. 2013 Jul;260(7):1709-13. doi: 10.1007/s00415-012-6695-z. Epub 2012 Oct 9.
In multiple sclerosis (MS), physical and cognitive deficits not only reflect structural damage, but also functional imbalance in and between brain networks. Resting-state functional magnetic resonance imaging (fMRI) allows one to investigate intrinsic, synchronized brain activity across the whole brain, and to measure the degree of functional correlation between different cortical regions. This review describes the major findings obtained in MS patients at different clinical stages using resting state fMRI, and discusses how the use of fMRI techniques may improve our ability to identify novel biomarkers useful in the context of the diagnostic work-up, establishing prognosis and monitoring treatment.
在多发性硬化症 (MS) 中，身体和认知缺陷不仅反映了结构损伤，还反映了大脑网络内部和之间的功能失衡。静息态功能磁共振成像 (fMRI) 可用于研究整个大脑的内在、同步脑活动，并测量不同皮质区域之间功能相关性的程度。本综述描述了使用静息态 fMRI 在不同临床阶段的 MS 患者中获得的主要发现，并讨论了 fMRI 技术的应用如何提高我们识别在诊断、预后和监测治疗中有用的新型生物标志物的能力。
