Horacek M, Möhlenkamp S, Mahabadi A A, Churzidse S, Moebus S, Jöckel K-H, Erbel R
Westdeutsches Herzzentrum, Klinik für Kardiologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
Herz. 2012 Nov;37(7):721-7. doi: 10.1007/s00059-012-3684-z.
Regional disparities in the prevalence of arterial hypertension in Germany have been reported in population-based surveys. An analysis comparing the SHIP study in the north-eastern region of Germany (1997-2001) with the MONICA/KORA-S4 study (1999-2001) in the south-west of Germany showed a significantly higher age-adjusted prevalence in the north-eastern population. The Heinz Nixdorf Recall Study is a population based prospective cohort study designed to assess cross-sectional and longitudinal data of risk factors, subclinical signs of atherosclerosis and cardiovascular endpoints in the Ruhr area of Germany. A total of 4,443 subjects without coronary artery disease aged 45-75 years could be included between 2000 und 2003 and the prevalence of hypertension, defined by JNC-7, was 63% in men and 52% in women. Low rates of hypertension awareness, treatment and control rates in population-based surveys as well as in recently published high risk cohorts with known coronary artery disease in Germany elucidate the need to optimize the strategies of screening, treatment and follow-up in primary and secondary prevention. Coronary artery calcification was demonstrated to be an independent risk factor for cardiovascular endpoints even in the stage of prehypertension. The risk-benefit ratio for an early treatment of these patients could be improved by advanced risk stratification, assessing the level of coronary artery calcification.
基于人群的调查已报告了德国动脉高血压患病率的地区差异。一项分析将德国东北部地区的SHIP研究(1997 - 2001年)与德国西南部的MONICA/KORA - S4研究(1999 - 2001年)进行比较,结果显示东北部人群经年龄调整后的患病率显著更高。海因茨·尼克斯多夫召回研究是一项基于人群的前瞻性队列研究,旨在评估德国鲁尔地区危险因素、动脉粥样硬化亚临床体征和心血管终点的横断面及纵向数据。在2000年至2003年期间,共纳入了4443名年龄在45 - 75岁之间无冠心病的受试者,按照美国国家联合委员会第7版(JNC - 7)定义的高血压患病率,男性为63%,女性为52%。基于人群的调查以及德国近期发表的已知患有冠心病的高危队列中,高血压知晓率、治疗率和控制率较低这一情况表明,有必要优化一级和二级预防中的筛查、治疗及随访策略。冠状动脉钙化被证明即使在高血压前期阶段也是心血管终点的独立危险因素。通过先进的风险分层,评估冠状动脉钙化水平,可以改善这些患者早期治疗的风险效益比。