School of Medical Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.
Cancer Chemother Pharmacol. 2012 Nov;70(5):627-35. doi: 10.1007/s00280-012-1989-5. Epub 2012 Sep 30.
Chemotherapy-induced gut toxicity (CIGT) is a frequent, debilitating and dose-limiting side effect of anti-cancer cytotoxic therapies. Despite much research, many of the underlying mechanisms remain poorly understood. Recently, there has been renewed interest in the role that intestinal permeability and tight junctions play in the pathogenesis of chemotherapy-induced gut toxicity. Tight junctions have been linked with many of the known hall marks of toxicity including pro-inflammatory cytokines and pathogenic bacteria. In this critical review, we highlight the research literature addressing modifications in tight junctions following chemotherapy administration and how tight junctions may be implicated in the pathophysiology of CIGT.
化疗引起的肠道毒性（CIGT）是癌症细胞毒疗法的一种常见、使人虚弱且剂量受限的副作用。尽管进行了大量研究，但许多潜在机制仍未得到很好的理解。最近，人们对肠道通透性和紧密连接在化疗引起的肠道毒性发病机制中的作用重新产生了兴趣。紧密连接与许多已知的毒性标志有关，包括促炎细胞因子和致病性细菌。在这篇批判性综述中，我们强调了研究文献中关于化疗后紧密连接变化的内容，以及紧密连接如何与 CIGT 的病理生理学相关。
