前列腺素E2输注对胎羊胎儿血浆促肾上腺皮质激素、催乳素和皮质醇浓度的影响。

The effect of prostaglandin E2 infusion in the fetal lamb on fetal plasma ACTH, prolactin and cortisol concentrations.

作者信息

Ratter S, Rees L H, Landon J R, Hillier K, Jansen C A, Beck N F, Lowe K C, Thomas A L, Nathanielsz P W

出版信息

Prostaglandins. 1979 Jul;18(1):101-16. doi: 10.1016/s0090-6980(79)80028-3.

Abstract

PGE2 (2 micrograms/min) has been infused for 1h into the fetal jugular vein of 8 chronically catheterized fetuses on 13 occasions from 112 to 138 days gestation. Infusion of ethanol vehicle alone was conducted in fetuses from 111-139 days gestation. PGE2 administration produced a significant increase in fetal plasma cortisol after 30 min. No significant change was observed in fetal plasma prolactin concentration. Fetal plasma ACTH concentration was significantly elevated above resting concentration after 30 min. of PGE2 infusion. Metabolic clearance rate of PGE2 was 860 ml/min or 350 ml/kg/min. Intrauterine pressure was not changes during the infusion at any gestational age.

摘要

在妊娠112至138天期间，对8只长期插管的胎儿的颈静脉进行了13次前列腺素E2（PGE2，2微克/分钟）输注，持续1小时。对妊娠111 - 139天的胎儿单独输注乙醇载体。输注PGE2 30分钟后，胎儿血浆皮质醇显著增加。胎儿血浆催乳素浓度未观察到显著变化。输注PGE2 30分钟后，胎儿血浆促肾上腺皮质激素（ACTH）浓度显著高于静息浓度。PGE2的代谢清除率为860毫升/分钟或350毫升/千克/分钟。在任何孕周的输注过程中，子宫内压力均未发生变化。