School of Life Sciences, University of Glasgow, Glasgow, United Kingdom.
J Muscle Res Cell Motil. 2012 Oct;33(5):297-300. doi: 10.1007/s10974-012-9326-5. Epub 2012 Sep 28.
This obituary provides some detail and background to the life and work of a pioneer of muscle physiology, Rolf Niedergerke, who died in December 2011 aged 90. His name is perhaps most widely known for his role in the discovery of the sliding filament mechanism of muscle contraction in collaboration with Andrew Huxley (which complemented the independent studies of HE Huxley and Jean Hanson). His other major contributions were to the 'calcium story' of muscle activation, particularly for the heart. In a long career, his intellectual and experimental excellence contributed some keystones of our present understanding of the role of cellular Ca(2+) in muscle contraction and cardiac excitation-contraction coupling and of the Ca-Na exchange process.
这篇讣告提供了肌肉生理学先驱 Rolf Niedergerke 的生平与工作的一些细节和背景，他于 2011 年 12 月去世，享年 90 岁。他的名字因与 Andrew Huxley 合作发现肌肉收缩的滑行丝机制而广为人知（这与 HE Huxley 和 Jean Hanson 的独立研究相辅相成）。他的另一项重大贡献是肌肉激活的“钙故事”，特别是心脏。在漫长的职业生涯中，他的智慧和实验能力为我们目前对细胞 Ca(2+)在肌肉收缩和心脏兴奋-收缩偶联以及 Ca-Na 交换过程中的作用的理解做出了一些重要贡献。
