Cuadrado Daniel G, Leacche Marzia, Byrne John G
Department of Cardiac Surgery, Vanderbilt University Medical Center, 1215 21st Avenue South, Nashville, TN, 37232, USA.
Curr Treat Options Cardiovasc Med. 2012 Dec;14(6):584-93. doi: 10.1007/s11936-012-0211-8.
Valvular heart disease imposes varying degrees of stress on the myocardium, which, untreated, leads to eventual ventricular dysfunction. The pathophysiologic mechanisms by which these lesions act depend not only on the affected valve, but also the degree to which they causes stenosis, regurgitation, or both. The goal of patient treatment is to identify and correct the defect before irreversible ventricular changes have occurred. Historically, the conventional surgical approach for valvular disease was via median sternotomy. Minimally invasive valve surgery (MIVS) refers to alternative surgical techniques, which avoid the trans-sternal approach. The objective is to (1) minimize surgical trauma, (2) reduce blood utilization, and (3) hasten postoperative convalesce. These goals are accomplished through the use of partial sternal, para-sternal, or thoracotomy incisions and can be adapted to robotic technologies. As with all evolving surgical techniques, the therapeutic aim of valve repair or replacement must be performed at or above the same standard of conventional surgery. Outcomes must not be sacrificed for the sake of better cosmesis. In addition, percutaneous catheter-based valvular interventions have seen rapid advances. These emerging technologies have dramatically broadened the therapeutic options, especially for an ever-increasing group of high-risk patients. As expected with all minimally invasive techniques, the major differences in the hard outcomes of mortality and major morbidity are seen in these highest risk groups. However, intermediate and low risk patients receive a tremendous benefit with regard to shortened hospital stay and quicker functional recovery. With the myriad of interventional options now available, the clinical challenge now is how best to individualize the treatment approach to a given patient providing the most durable result in order to alleviate symptoms and preserve myocardial function.
心脏瓣膜病会给心肌带来不同程度的压力,若不治疗,最终会导致心室功能障碍。这些病变起作用的病理生理机制不仅取决于受影响的瓣膜,还取决于它们导致狭窄、反流或两者兼有的程度。患者治疗的目标是在不可逆转的心室变化发生之前识别并纠正缺陷。从历史上看,治疗瓣膜病的传统手术方法是通过正中胸骨切开术。微创瓣膜手术(MIVS)是指避免经胸骨入路的替代手术技术。其目的是:(1)将手术创伤降至最低;(2)减少血液使用量;(3)加速术后康复。这些目标通过使用部分胸骨、胸骨旁或开胸切口来实现,并且可以应用于机器人技术。与所有不断发展的手术技术一样,瓣膜修复或置换的治疗目的必须达到或高于传统手术的相同标准。绝不能为了更好的美观效果而牺牲治疗结果。此外,基于经皮导管的瓣膜介入技术也取得了快速进展。这些新兴技术极大地拓宽了治疗选择,尤其是对于越来越多的高危患者群体。正如所有微创技术所预期的那样,在这些最高风险组中可以看到死亡率和主要发病率等硬性结果的主要差异。然而,中低风险患者在缩短住院时间和更快功能恢复方面获得了巨大益处。鉴于现在有众多的介入选择,目前的临床挑战是如何最好地针对特定患者个体化治疗方法,以提供最持久的结果,从而缓解症状并保留心肌功能。