Fang Yu-Jing, Wang Guo-Qiang, Lu Zhen-Hai, Zhang Lin, Li Ji-Bin, Wu Xiao-Jun, Ding Pei-Rong, Ou Qing-Jian, Zhang Mei-Fang, Jiang Wu, Pan Zhi-Zhong, Wan De-Sen
Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.
Tumour Biol. 2012 Dec;33(6):2227-35. doi: 10.1007/s13277-012-0484-2. Epub 2012 Sep 29.
Estrogen receptor beta (ERβ) and TROP2 expressed in colon carcinoma and might play an important role there. We explored the relationship of ERβ and TROP2 expression with the prognosis of early-stage colon cancer. ERβ and TROP2 levels were assessed by immunohistochemistry in normal mucosa and tumoral tissues from 220 Chinese patients with T(3)N(0)M(0) (stage IIa) and T(4)N(0)M(0) (stage IIb) colon cancer in the Cancer Center, Sun Yat-sen University, who underwent curative surgical resection between 1995 and 2003. The Cox proportional hazards regression model was applied to analyze the overall survival (OS) data, and the ROC curve, Kaplan-Meier estimate, log rank test, and Jackknife method were used to show the effect of ERβ and TROP2 expression at different stages of cancer. The 5-year survival rates were not significantly different between the patients with stage IIa and stage IIb colon cancer (83 vs. 80 %, respectively). The high expression of ERβ was related to decreasing OS in stage IIa and stage IIb colon cancer, while the high expression of TROP2 was related to decreasing OS in stage IIb colon cancer. The expression of ERβ and TROP2 has tumor-suppressive and tumor-promoting effect in stage IIa and stage IIb colon cancer, respectively.
雌激素受体β（ERβ）和TROP2在结肠癌中表达，可能在其中发挥重要作用。我们探讨了ERβ和TROP2表达与早期结肠癌预后的关系。通过免疫组织化学方法评估了220例1995年至2003年间在中山大学肿瘤防治中心接受根治性手术切除的T(3)N(0)M(0)（IIa期）和T(4)N(0)M(0)（IIb期）结肠癌中国患者正常黏膜和肿瘤组织中的ERβ和TROP2水平。应用Cox比例风险回归模型分析总生存（OS）数据，并使用ROC曲线、Kaplan-Meier估计、对数秩检验和刀切法来显示ERβ和TROP2表达在癌症不同阶段的作用。IIa期和IIb期结肠癌患者的5年生存率无显著差异（分别为83%和80%）。ERβ高表达与IIa期和IIb期结肠癌患者OS降低有关，而TROP2高表达与IIb期结肠癌患者OS降低有关。ERβ和TROP2的表达在IIa期和IIb期结肠癌中分别具有肿瘤抑制和肿瘤促进作用。
