O'Donnell J P, Azzaro A J, Urquilla P R
Res Commun Chem Pathol Pharmacol. 1979 Nov;26(2):243-51.
(3,4-Dihydroxybenzyl)-2-imidazoline (DHBI) was prepared and evaluated for dopamine receptor activity by studying its relaxant effects in the rabbit isolated renal and ear arteries and by measuring its ability to enhance dopamine sensitive adenylate cyclase in the rat striatum. DHBI relaxed both the rabbit isolated renal and ear arteries in the presence of phenoxybenzamine (2. 9 X 10(-5)M) and propranolol (3.4 X 10(-7) M) while dopamine and the specific renal dopamine agonist 6,7-dihydroxy-2-aminotetrahydronaphthalene (6,7-ADTN) demonstrated a ratio of specificity for the renal versus the less responsive ear artery. DHBI did not cause a typical increase in adenylate cyclase activity, however DHBI did attenuate the stimulatory a
制备了(3,4 - 二羟基苄基)-2 - 咪唑啉（DHBI），并通过研究其对兔离体肾动脉和耳动脉的舒张作用以及测量其增强大鼠纹状体中多巴胺敏感腺苷酸环化酶的能力来评估其多巴胺受体活性。在存在苯氧苄胺（2.9×10⁻⁵M）和普萘洛尔（3.4×10⁻⁷M）的情况下，DHBI使兔离体肾动脉和耳动脉均舒张，而多巴胺和特异性肾多巴胺激动剂6,7 - 二羟基 - 2 - 氨基四氢萘（6,7 - ADTN）对肾动脉与反应较弱的耳动脉表现出特异性比值。然而，DHBI并未引起腺苷酸环化酶活性的典型增加，不过DHBI确实减弱了刺激作用。
