Keller Joseph J, Kang Jiunn-Horng, Lin Herng-Ching
School of Health Care Administration, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Arthritis Rheum. 2013 Jan;65(1):167-73. doi: 10.1002/art.37746.
Ankylosing spondylitis (AS) is one type of chronic inflammatory rheumatic disease. It has been suggested that rheumatic diseases may have additional underlying factors in common with chronic periodontitis. However, few studies have addressed the possible link between AS and chronic periodontitis. We undertook the present case-control study to investigate the possible association between AS and chronic periodontitis using a population-based data set in Taiwan.
We conducted this study by using administrative claims data sourced from the Taiwan National Health Insurance program database. Our study included 6,821 AS patients and 34,105 randomly selected controls. Conditional logistic regression analyses were performed to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) for prior chronic periodontitis among AS patients and matched controls.
There was a significant difference in the prevalence of prior chronic periodontitis between patients and controls (41.5% versus 25.9%; P<0.001). Conditional logistic regression analysis revealed that patients were more likely than controls to have been previously diagnosed as having chronic periodontitis (adjusted OR 1.84 [95% CI 1.74-1.98]). We further found that patients were only 1.70 (95% CI 1.56-1.89) times more likely than controls to have undergone a gingivectomy or periodontal flap operation (all patients had a history of chronic periodontitis) within the 5 years preceding the index date. After excluding those who had undergone either a gingivectomy or periodontal flap surgery, patients were even more likely than controls to have been previously diagnosed as having chronic periodontitis (adjusted OR 2.04 [95% CI 1.93-2.15]).
This study detected an association between AS and a prior diagnosis of chronic periodontitis.
强直性脊柱炎（AS）是一种慢性炎症性风湿性疾病。有研究表明，风湿性疾病可能与慢性牙周炎存在其他共同的潜在因素。然而，很少有研究探讨AS与慢性牙周炎之间的可能联系。我们进行了本病例对照研究，以利用台湾基于人群的数据集调查AS与慢性牙周炎之间的可能关联。
我们通过使用源自台湾国民健康保险计划数据库的行政索赔数据进行本研究。我们的研究包括6821例AS患者和34105例随机选择的对照。进行条件逻辑回归分析，以计算AS患者和匹配对照中既往慢性牙周炎的比值比（OR）和95%置信区间（95%CI）。
患者和对照之间既往慢性牙周炎的患病率存在显著差异（41.5%对25.9%；P<0.001）。条件逻辑回归分析显示，患者比对照更有可能曾被诊断为患有慢性牙周炎（调整后的OR为1.84[95%CI为1.74 - 1.98]）。我们进一步发现，在索引日期前5年内，患者接受牙龈切除术或牙周翻瓣手术（所有患者均有慢性牙周炎病史）的可能性仅比对照高1.70倍（95%CI为1.56 - 1.89）。在排除接受过牙龈切除术或牙周翻瓣手术的患者后，患者比对照更有可能曾被诊断为患有慢性牙周炎（调整后的OR为2.04[95%CI为1.93 - 2.15]）。
本研究发现AS与既往慢性牙周炎诊断之间存在关联。
