National Medical Laser Centre, University College London, United Kingdom.
J Natl Compr Canc Netw. 2012 Oct 1;10 Suppl 2:S69-74. doi: 10.6004/jnccn.2012.0180.
Although photodynamic therapy (PDT) has been used successfully to treat an assortment of different types of cancer, it has yet to reach the level of mainstream medicine on either side of the Atlantic. Unsubstantiated claims of PDT's efficacy in the past may be part of the reason for this. However, perhaps the main obstacle to PDT's endorsement by conventional medicine is the limited number of high-quality randomized controlled trials (RCTs) comparing it with relevant comparators for all meaningful outcomes, including effectiveness, safety, adverse events, quality of life, survival, and cost. Based on a Health Technology Assessment report on the current status of PDT and consultation with professional groups, specialist societies, and clinical study groups in the United Kingdom, this article explores the current clinical guidelines for use of PDT in cancer treatment and the dearth of supportive data from RCTs.
尽管光动力疗法 (PDT) 已成功用于治疗多种不同类型的癌症，但它尚未在大西洋两岸达到主流医学的水平。过去 PDT 疗效的未经证实的说法可能是其中部分原因。然而， PDT 被传统医学认可的主要障碍可能是缺乏高质量的随机对照试验 (RCT) 来比较它与所有有意义的结局（包括有效性、安全性、不良事件、生活质量、生存和成本）的相关对照药物。基于对 PDT 当前状况的一份健康技术评估报告以及与英国的专业团体、专业协会和临床研究小组的协商，本文探讨了 PDT 在癌症治疗中的当前临床指南以及 RCT 支持数据的缺乏。
