Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
J Neurosci. 2012 Oct 10;32(41):14109-17. doi: 10.1523/JNEUROSCI.3327-12.2012.
The prevalence of autism spectrum disorder (ASD) is as high as 1 in 100 individuals and is a heavy burden to society. Thus, identifying causes and treatments is imperative. Here, we briefly review the topics covered in our 2012 Society for Neuroscience Mini-Symposium entitled "Integrative Approaches Using Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to ASD's Social Dysfunction." This work is not meant to be a comprehensive review of oxytocin and prosocial behavior. Instead, we wish to share the newest findings on the effects of oxytocin on social behavior, the brain, and the social dysfunction of ASD at the molecular, genetic, systemic, and behavior levels, in varied subjects ranging from animal models to humans suffering from autism for the purpose of promoting further study for developing the clinical use of oxytocin in treating ASD.
自闭症谱系障碍（ASD）的患病率高达每 100 人中就有 1 人，给社会带来了沉重的负担。因此，确定病因和治疗方法至关重要。在这里，我们简要回顾一下我们在 2012 年神经科学学会小型研讨会中讨论的主题，该研讨会题为“使用催产素增强亲社会行为的综合方法：从动物和人类的社会行为到 ASD 的社交功能障碍”。这项工作并不是对催产素和亲社会行为的全面综述。相反，我们希望分享催产素对社会行为、大脑和 ASD 的社交功能障碍的最新发现，这些发现涉及从动物模型到自闭症患者的不同对象，涵盖了从分子、遗传、系统到行为层面，旨在促进进一步研究，以开发催产素在治疗 ASD 方面的临床应用。
