Zubrikhina G N, Manakhova L Iu, Solov'eva E A, Lebedeva N B, Khaĭretdinova Z Kh, Kachalov V K, Lebedev A I
Vopr Onkol. 1990;36(1):81-5.
The Hemalog D automatic cytochemical analyser was used to assess changes in the levels of neutrophil peroxidase and monocyte non-specific esterase in 194 cancer patients undergoing radiation and chemotherapy. Radiotherapy in the dose of 30-48 Gy did not affect functional activity of blood leukocytes. Combination chemotherapy induced moderate or severe leukopenia in 72.7% of cases. A decrease in the enzymatic activity of neutrophils and monocytes was observed in patients with normal and slightly decreased leukocyte counts. In patients with severe leukopenia, elevated levels of peroxidase and non-specific esterase in leukocytes were found.
采用Hemalog D自动细胞化学分析仪评估194例接受放疗和化疗的癌症患者中性粒细胞过氧化物酶和单核细胞非特异性酯酶水平的变化。30 - 48 Gy剂量的放疗未影响血液白细胞的功能活性。联合化疗导致72.7%的病例出现中度或重度白细胞减少。白细胞计数正常和轻度降低的患者中观察到中性粒细胞和单核细胞的酶活性降低。在严重白细胞减少的患者中，发现白细胞中过氧化物酶和非特异性酯酶水平升高。
