赖氨酸布洛芬致反复肠穿孔：一例报告
Repeated bowel perforations with Ibuprofen lysine: a case report.
作者信息
Peitz Gregory J, Hoie Eric B, Hoy Shannon, Anderson-Berry Ann
机构信息
Creighton University Medical Center.
出版信息
J Pediatr Pharmacol Ther. 2008 Jul;13(3):166-9. doi: 10.5863/1551-6776-13.3.166.
Abstract
Non-steroidal anti-inflammatory drugs (NSAID) have been used to close the patent ductus arteriosus in neonates for over two decades. Ibuprofen lysine, a parenteral NSAID, is labeled for the treatment of patent ductus arteriosus in neonates who do not respond to conventional medical management. While sharing many of the same adverse effects as indomethacin, spontaneous bowel perforation has not been reported. We describe a premature infant that experienced isolated bowel perforations after treatment with ibuprofen lysine for symptomatic patent ductus arteriosus.
摘要
二十多年来，非甾体类抗炎药（NSAID）一直被用于闭合新生儿动脉导管未闭。赖氨酸布洛芬，一种胃肠外NSAID，被标注用于治疗对传统药物治疗无反应的新生儿动脉导管未闭。虽然与吲哚美辛有许多相同的不良反应，但尚未有自发性肠穿孔的报道。我们描述了一名早产儿，在用赖氨酸布洛芬治疗有症状的动脉导管未闭后发生了孤立性肠穿孔。
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