一名不完全川崎病合并冠状动脉瘤婴儿的溶栓与抗血小板联合治疗
Combination thrombolytic and anti-platelet therapies in an infant with incomplete kawasaki disease and coronary aneurysms.
作者信息
Johnson Peter N, Kuhn Robert J
机构信息
Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy at the University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
出版信息
J Pediatr Pharmacol Ther. 2008 Oct;13(4):242-50. doi: 10.5863/1551-6776-13.4.242.
A 3-month-old infant was transferred to our facility with persistent fever and concerns for septic shock. A 2-D echocardiogram revealed multiple coronary aneurysms and axillary and coronary artery thrombi, and a diagnosis of incomplete Kawasaki disease (KD) was established. Aggressive therapies including intravenous immunoglobulins, enoxaparin, abciximab, aspirin, and alteplase were used to decrease the size of the coronary aneurysms and inhibit further thrombus formation. After minimal change in the size of coronary aneurysms and in thrombus formation, clopidogrel was added. Approximately 2 weeks after initiation of these therapies, a decrease in the coronary aneurysm size was noted with no signs of thrombus. This case documents successful use of thrombolytic and combination anti-platelet agents (i.e., clopidogrel, abciximab, and aspirin) in an infant with KD and cardiovascular sequelae.
一名3个月大的婴儿因持续发热并疑似感染性休克被转至我院。二维超声心动图显示多个冠状动脉瘤以及腋窝和冠状动脉血栓，确诊为不完全川崎病（KD）。采用了包括静脉注射免疫球蛋白、依诺肝素、阿昔单抗、阿司匹林和阿替普酶在内的积极治疗方法，以减小冠状动脉瘤的大小并抑制血栓进一步形成。在冠状动脉瘤大小和血栓形成几乎没有变化后，加用了氯吡格雷。开始这些治疗约2周后，冠状动脉瘤大小减小，且无血栓迹象。本病例证明了在患有KD和心血管后遗症的婴儿中成功使用了溶栓药物和联合抗血小板药物（即氯吡格雷、阿昔单抗和阿司匹林）。
Zotero 插件