Hari B N Vedha, Praneetha T, Prathyusha T, Mounika K, Devi D Ramya
Department of Pharmacy, SCBT, SASTRA University, Thirumalaisamudram, Thanjavur, Tamil Nadu, India.
J Adv Pharm Technol Res. 2012 Jul;3(3):182-7. doi: 10.4103/2231-4040.101015.
The starch was isolated from jackfruit seeds and evaluated for its preformulation properties, like tapped density, bulk density, and particle size. The fourier transform infrared (FTIR) analysis was done and compared with that of the commercially available starch which confirmed the properties. Using the various concentrations of jackfruit seed starch, the microspheres were prepared, combining with gelatin by ionotropic gelation technique. The developed microspheres were subjected to analysis of particle size, drug content, entrapment efficiency, and percentage yield. The spectral analysis confirmed the presence of drug and absence of interactions. Scanning electron microscope image showed that the particles were in spherical shape with a rough surface. The in vitro drug release in water for 12 hours proved to be in the range of 89 to 100%. The various kinetic models were applied using release data to confirm the mechanism of drug. It was concluded that the jackfruit starch-gelatin microspheres gave satisfactory results and met pharmacopieal limits.
从菠萝蜜种子中分离出淀粉，并对其预制剂性质进行评估，如振实密度、堆密度和粒径。进行了傅里叶变换红外光谱（FTIR）分析，并与市售淀粉的分析结果进行比较，以确认其性质。采用不同浓度的菠萝蜜种子淀粉，通过离子凝胶技术与明胶结合制备微球。对所制备的微球进行粒径、药物含量、包封率和产率分析。光谱分析证实了药物的存在以及不存在相互作用。扫描电子显微镜图像显示，颗粒呈球形，表面粗糙。在水中12小时的体外药物释放率为89%至100%。应用各种动力学模型分析释放数据以确定药物释放机制。结果表明，菠萝蜜淀粉-明胶微球效果良好，符合药典标准。
