Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Breastfeed Med. 2013 Feb;8(1):8-15. doi: 10.1089/bfm.2012.0048. Epub 2012 Oct 11.
There is conflicting evidence as to whether duration of lactation may decrease the risk of subsequent development of an unfavorable maternal metabolic profile, including overweight and obesity. We hypothesized that duration of lactation is associated with a more favorable metabolic profile and healthier anthropometric measurements.
Ninety-eight parous women were studied from the Norwegian EBBAI-study (Energy Balance and Breast cancer Aspects-study), a cross-sectional study of healthy premenopausal women 25-35 years old. Historical lactation data were collected, anthropometric measurements were taken, fasting blood samples (for serum glucose, triglycerides, total cholesterol, and high-density lipoprotein cholesterol) were drawn, and women were asked to fill in a precoded food diary.
Mean time since last birth was 4.7 years, mean number of children was 1.9, mean total duration of lactation was 19 months, and average length of lactation per child was 10.3 months. Women who on average lactated for less than 10 months per child had higher mean levels of fasting serum glucose (5.2 mmol/L vs. 5.0 mmol/L, p=0.04), serum triglyceride (0.91 mmol/L vs. 0.66 mmol/L, p=0.001), and serum cholesterol (4.78 mmol/L vs. 4.32 mmol/L, p=0.004) and a higher waist-to-hip ratio (0.81 vs. 0.77, p=0.001) than women who lactated for 10 months or more per child. The inverse association between average length of lactation per child and waist-to-hip ratio persisted after adjustment for potential confounders.
These results support the hypothesis that duration of lactation may be associated with a healthier metabolic profile and healthier anthropometric measurements, especially lipid levels and waist-to-hip ratio, even years after weaning.
关于哺乳期持续时间是否会降低随后发生不良产妇代谢特征（包括超重和肥胖）的风险，目前存在相互矛盾的证据。我们假设哺乳期持续时间与更有利的代谢特征和更健康的人体测量指标有关。
我们对 98 名经挪威 EBBAI 研究（能量平衡和乳腺癌方面研究）筛选的经产妇女进行了研究，该研究为一项 25-35 岁健康绝经前妇女的横断面研究。收集了历史哺乳数据，进行了人体测量，抽取了空腹血样（用于检测血清葡萄糖、甘油三酯、总胆固醇和高密度脂蛋白胆固醇），并要求妇女填写预先编码的食物日记。
末次分娩后平均时间为 4.7 年，平均生育子女数为 1.9 个，平均总哺乳期为 19 个月，每个孩子的平均哺乳期长度为 10.3 个月。平均每个孩子哺乳期不足 10 个月的妇女空腹血清葡萄糖（5.2mmol/L 比 5.0mmol/L，p=0.04）、血清甘油三酯（0.91mmol/L 比 0.66mmol/L，p=0.001）和血清胆固醇（4.78mmol/L 比 4.32mmol/L，p=0.004）水平较高，腰臀比（0.81 比 0.77，p=0.001）也较高，而每个孩子哺乳期持续 10 个月或更长时间的妇女则不然。在校正潜在混杂因素后，每个孩子的平均哺乳期长度与腰臀比之间的负相关关系仍然存在。
这些结果支持这样一种假设，即哺乳期持续时间可能与更健康的代谢特征和更健康的人体测量指标有关，尤其是在断奶多年后，其与血脂水平和腰臀比有关。
