Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
Reprod Toxicol. 2012 Dec;34(4):607-13. doi: 10.1016/j.reprotox.2012.09.008. Epub 2012 Oct 8.
Triclosan is an antimicrobial additive in many personal care and household products, and evidence indicates that it can be estrogenic. As estrogen elevations can disrupt blastocyst implantation, we examined the influence of triclosan on implantation in inseminated mice. Doses of 18 and 27 mg/animal/day (about 523 and 785 mg/kg/day) on gestational days (GD) 1-3 reduced the number of implantation sites on GD 6. Single doses on GD 2 or 3 also reduced implantation sites. Subsequently, we examined triclosan in combination with bisphenol-A (BPA), which also can disrupt implantation. Although doses of 4 mg BPA (122 mg/kg) and 9 mg triclosan (262 mg/kg) on GD 1-3 were individually ineffective, in combination they reduced the number of implantation sites and also increased gestation length. All of these effects mimicked stronger effects of 17β-estradiol. These data are consistent with potential estrogenic properties of triclosan, and show that it can act together with BPA.
三氯生是许多个人护理和家用产品中的一种抗菌添加剂，有证据表明它具有雌激素特性。由于雌激素水平升高会破坏囊胚着床，我们研究了三氯生对受精小鼠着床的影响。在妊娠第 1-3 天给予 18 和 27 mg/动物/天（约 523 和 785 mg/kg/天）的剂量可减少妊娠第 6 天的着床部位数量。妊娠第 2 或 3 天单次给予这些剂量也会减少着床部位数量。随后，我们研究了三氯生与双酚 A（BPA）的联合作用，BPA 也会破坏着床。尽管在妊娠第 1-3 天给予 4 毫克 BPA（122 毫克/千克）和 9 毫克三氯生（262 毫克/千克）的剂量单独使用时没有效果，但联合使用时，它们减少了着床部位的数量，并延长了妊娠时间。所有这些作用都类似于 17β-雌二醇更强的作用。这些数据与三氯生潜在的雌激素特性一致，并表明它可以与 BPA 共同作用。
