Corongiu B, Roth M
Laboratoire Central de Chimie Clinique, Hôpital Cantonal Universitaire de Genève, Suisse.
Ann Biol Clin (Paris). 1990;48(1):9-15.
This review discusses the knowledge on the transformation of bilirubin into urobilinoids before its elimination from the organism. The following aspects are presented: mechanism of bilirubin reduction by anaerobic intestinal bacteria, structure of the resulting urobilinoids, and enterohepatic circulation of the latter. Investigations on the reduction of bilirubin by intestinal bacteria in vitro are described, and the diagnostic value of urobilinoids determination is discussed.
本综述讨论了胆红素在从机体消除之前转化为尿胆素原的相关知识。介绍了以下几个方面:厌氧肠道细菌还原胆红素的机制、所生成尿胆素原的结构以及后者的肠肝循环。描述了体外对肠道细菌还原胆红素的研究,并讨论了尿胆素原测定的诊断价值。