Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, 138 Xianlin Road, 210046, Nanjing, Jiangsu, People's Republic of China.
Med Chem. 2013 Nov;9(7):947-54. doi: 10.2174/1573406411309070008.
A series of ferulic acid amides with extended P1' groups were synthesized and tested for their inhibitory activities on matrix metalloproteinase (MMP)-1, MMP-2, and MMP-9. Preliminary structure-activity relationship analysis and docking studies indicated that ferulic acid amides with electron-donating groups at the amino phenyl ring showed better inhibitory activities and selectivity than those with electron-withdrawing groups. Compound 3e, which had a hydroxyl group at meta-position of amino phenyl ring, showed considerable inhibitory activities against MMP-2, MMP-9 and best selectivity over MMP-1. The findings of this study would provide information for the exploitation and utilization of ferulic acid as MMP inhibitor for metastatic tumor treatment.
合成了一系列具有延伸 P1' 基团的阿魏酸酰胺，并测试了它们对基质金属蛋白酶（MMP）-1、MMP-2 和 MMP-9 的抑制活性。初步的构效关系分析和对接研究表明，在氨基苯环上具有供电子基团的阿魏酸酰胺比具有吸电子基团的阿魏酸酰胺具有更好的抑制活性和选择性。在氨基苯环的间位具有羟基的化合物 3e 对 MMP-2、MMP-9 具有相当的抑制活性，对 MMP-1 的选择性最好。本研究的结果将为阿魏酸作为基质金属蛋白酶抑制剂用于转移性肿瘤治疗的开发和利用提供信息。
