Department of Chemistry, University of California-Davis , One Shields Avenue, Davis, California, USA.
J Med Chem. 2013 Jan 24;56(2):388-405. doi: 10.1021/jm3010114. Epub 2012 Nov 6.
The incorporation of silicon and synthesis of organosilicon small molecules provide unique opportunities for medicinal applications. The biological investigation of organosilicon small molecules is particularly interesting because of differences in their chemical properties that can contribute to enhanced potency and improved pharmacological attributes. Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.
硅的掺入和有机硅小分子的合成为药物应用提供了独特的机会。有机硅小分子的生物学研究特别有趣,因为它们的化学性质不同,可以提高效力和改善药理学特性。讨论了抑制剂设计、成像、药物释放技术和抑制剂结合的映射等应用。