Department of Pharmacy, General Hospital of the Air Force , Beijing China.
Drug Dev Ind Pharm. 2013 Nov;39(11):1712-9. doi: 10.3109/03639045.2012.730527. Epub 2012 Oct 15.
Characterization and antitumor activity of basic fibroblast growth factor-mediated active targeting doxorubicin microbubbles (bFGF-DOX-MB) were investigated. Pluronic F68 with chemical conjugation of doxorubicin (DOX-P) and peptide KRTGQYKLC-conjugated DSPE-PEG2000 were prepared. bFGF-DOX-MB had a normal distribution of particle size, with average particle size of 2.7 μm. Using A549 mouse model, bFGF-DOX-MB combined ultrasound showed the best inhibition effect on tumor volume growth among all the test groups. Similar conclusion was obtained from experimental measurements of tumor weight change and blood cell count. From the results, chemotherapeutic drug inhibition on tumor growth could be enhanced by local ultrasound combined with active targeting bFGF-DOX-MB, which might provide a potential application for ultrasound-mediated chemotherapy.
研究了碱性成纤维细胞生长因子介导的主动靶向阿霉素微泡（bFGF-DOX-MB）的特性和抗肿瘤活性。制备了化学偶联阿霉素的 Pluronic F68（DOX-P）和肽 KRTGQYKLC 偶联的 DSPE-PEG2000。bFGF-DOX-MB 的粒径呈正态分布，平均粒径为 2.7μm。使用 A549 小鼠模型，bFGF-DOX-MB 联合超声在所有实验组中对肿瘤体积生长的抑制效果最佳。从肿瘤重量变化和血细胞计数的实验测量中也得到了类似的结论。结果表明，局部超声联合主动靶向 bFGF-DOX-MB 可以增强化疗药物对肿瘤生长的抑制作用，这可能为超声介导的化疗提供一种潜在的应用。
