Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia, 70910-900 Brasilia, DF, Brazil.
Drug Alcohol Depend. 2013 Feb 1;128(1-2):155-60. doi: 10.1016/j.drugalcdep.2012.08.020. Epub 2012 Oct 11.
Cocaine is a widely abused drug which can result in the establishment of addiction. The neurokinin3-receptor (NK3-R) has been linked to cocaine addiction by genetic, epigenetic, and pharmacological studies suggesting that a cocaine-induced increase in NK3-R signaling may contribute to the establishment of cocaine addiction-related behaviors.
Here we measured cocaine-induced sensitization of vigilance- and locomotor behaviors in marmoset monkeys (Callithrix penicillata) in an open field.
We found a sensitization of vigilance-related, but not locomotor behaviors after repeated cocaine (7mg/kg, i.p.) treatment. There was a cross-sensitization for scan frequency, but not of glance frequency, both vigilance-related behaviors, after repeated treatment with the NK3-R agonist senktide (0.2mg/kg, i.p.) given for 7 days, after a cocaine challenge (5mg/kg, i.p.).
These data suggest that in marmoset monkeys, repeated cocaine treatment leads to a sensitization of vigilance-related behaviors, which have a prominent role in spontaneously expressed activities in this species, but not of locomotor activity. Repeated activation of NK3-Rs can mimic some of the behavioral sensitization effect and may thus contribute to the establishment of cocaine related behaviors.
可卡因是一种广泛滥用的药物，可导致成瘾。神经激肽 3 受体（NK3-R）通过遗传、表观遗传和药理学研究与可卡因成瘾有关，这些研究表明，可卡因诱导的 NK3-R 信号增加可能有助于建立与可卡因成瘾相关的行为。
在这里，我们在开阔场中测量了食蟹猴（Callithrix penicillata）可卡因引起的警戒和运动行为的敏化。
我们发现，重复可卡因（7mg/kg，ip）治疗后，警戒相关行为而非运动行为出现敏化。在可卡因（5mg/kg，ip）挑战后，重复给予 NK3-R 激动剂 senktide（0.2mg/kg，ip）治疗 7 天，可引起扫描频率交叉敏化，但警戒相关行为中的注视频率无敏化。
这些数据表明，在食蟹猴中，重复可卡因处理会导致警戒相关行为敏化，而这些行为在该物种自发表达的活动中起着重要作用，但不会引起运动活动敏化。NK3-R 的重复激活可以模拟一些行为敏化效应，因此可能有助于建立与可卡因相关的行为。
