Takenaka Motoyasu, Iida Hiroki, Matsumoto Shigemi, Yamaguchi Shinobu, Yoshimura Noritaka, Miyamoto Maki
1Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Yanagido, Gifu City, Gifu, Japan.
Am J Hosp Palliat Care. 2013 Nov;30(7):734-6. doi: 10.1177/1049909112463416. Epub 2012 Oct 11.
Although paclitaxel is a commonly used anticancer drug, peripheral neuropathy may develop as a side effect. Worsening of the symptoms with time may cause patients who receive paclitaxel to give up their chemotherapy. Duloxetine, a serotonin- and norepinephrine-reuptake inhibitor, has been used to treat peripheral neuropathic pain. We report the case of a 68-year-old man with gastric cancer, who underwent gastrectomy and then received 8 cycles of chemotherapy involving weekly administrations of paclitaxel. Under this paclitaxel treatment, he complained of severe peripheral neuropathy, leading to a diminished quality of life. Following treatment with a combination of duloxetine and pregabalin, a remission of his symptoms was achieved. Duloxetine plus pregabalin therapy may be useful for the peripheral neuropathy induced by paclitaxel.
尽管紫杉醇是一种常用的抗癌药物，但外周神经病变可能作为副作用出现。随着时间推移症状加重可能导致接受紫杉醇治疗的患者放弃化疗。度洛西汀是一种5-羟色胺和去甲肾上腺素再摄取抑制剂，已被用于治疗外周神经性疼痛。我们报告了一例68岁胃癌男性患者，该患者接受了胃切除术，随后接受了8个周期的化疗，其中每周使用紫杉醇。在这种紫杉醇治疗下，他抱怨有严重的外周神经病变，导致生活质量下降。在用度洛西汀和普瑞巴林联合治疗后，他的症状得到缓解。度洛西汀加普瑞巴林治疗可能对紫杉醇诱导的外周神经病变有效。
