Chronic Diseases Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Bull Environ Contam Toxicol. 2012 Dec;89(6):1120-4. doi: 10.1007/s00128-012-0856-8. Epub 2012 Oct 14.
Excessive urinary calcium is the major risk of renal tubular dysfunction and urinary stone formation. We examined the association of elevated urinary cadmium with urinary stones and chronic kidney disease (CKD) in 1,085 study residents of 13 cadmium-contaminated villages. Elevated urinary cadmium was significantly correlated with urinary stone and CKD. Elevated urinary cadmium appeared to increase risk of urinary stone and CKD; ORs and 95 % CIs were 2.73 (1.16, 6.42) and 3.73 (2.50, 5.57) after adjusting for other co-variables. This study revealed that elevated urinary stone and CKD induced by cadmium might increase the risk of urinary stone and CKD.
尿钙过多是肾小管功能障碍和尿路结石形成的主要风险。我们在 13 个镉污染村的 1085 名研究居民中研究了尿镉升高与尿路结石和慢性肾脏病（CKD）的关系。尿镉升高与尿路结石和 CKD 呈显著相关性。尿镉升高似乎增加了尿路结石和 CKD 的风险；在调整其他协变量后，OR 值和 95%CI 分别为 2.73（1.16，6.42）和 3.73（2.50，5.57）。这项研究表明，镉引起的尿钙升高和 CKD 可能会增加尿路结石和 CKD 的风险。
