Faculty of Sport, Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal.
Int J Sports Med. 2013 Mar;34(3):274-80. doi: 10.1055/s-0032-1316365. Epub 2012 Oct 12.
β1-adrenergic receptors (ADRB1) and Gαs proteins (GNAS) play important roles in the regulation of cardiac function. The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 61 heart failure patients completed a 6-month exercise-training programme. Left ventricular ejection fraction (LVEF), mitral inflow velocities (deceleration time, and E/A ratio) and exercise tolerance (METs) were assessed at baseline and following exercise training. There were no associations between the studied variants and LVEF or E/A ratio measured at baseline and after exercise training. Deceleration time of early mitral flow was higher at baseline in GNAS -1211G allele carriers compared with -1211A allele homozygotes (P<0.05). Exercise training attenuated deceleration time in -1211G allele carriers (P<0.05) but not in -1211A allele homozygotes. Moreover, ADRB1 389Gly homozygotes had a greater training-induced increase in exercise tolerance than 389Arg homozygotes (P=0.04). This study shows that the functional GNAS -1121 G/A polymorphism is associated with diastolic function at baseline and in response to exercise training in heart failure patients. Furthermore, our data suggest that ADRB1 Arg389Gly polymorphism may influence exercise tolerance.
β1-肾上腺素能受体（ADRB1）和 Gαs 蛋白（GNAS）在心脏功能调节中发挥重要作用。本研究旨在探讨 ADRB1 Arg389Gly（rs1801253）、GNAS-1211 G/A（rs6123837）和 GNAS 2291 C/T（rs6026584）变体是否与心力衰竭患者的左心室功能和运动耐量相关。61 例心力衰竭患者完成了 6 个月的运动训练计划。在基线和运动训练后评估左心室射血分数（LVEF）、二尖瓣血流速度（减速时间和 E/A 比值）和运动耐量（METs）。在所研究的变体与基线和运动训练后的 LVEF 或 E/A 比值之间没有关联。与 -1211A 等位基因纯合子相比，GNAS-1211G 等位基因携带者的早期二尖瓣血流减速时间在基线时更高（P<0.05）。运动训练减弱了 -1211G 等位基因携带者的减速时间（P<0.05），但对 -1211A 等位基因纯合子没有影响。此外，ADRB1 389Gly 纯合子的运动耐量增加幅度大于 389Arg 纯合子（P=0.04）。本研究表明，功能性 GNAS-1121 G/A 多态性与心力衰竭患者的基础舒张功能以及对运动训练的反应有关。此外，我们的数据表明 ADRB1 Arg389Gly 多态性可能影响运动耐量。
