Schwartz S M, Weiss N S
Division of Public Health Sciences, Fred Hutchinson Cancer Research Cancer, Seattle, Washington 98104.
Cancer Res. 1990 Mar 15;50(6):1886-9.
To explore further the descriptive epidemiology of sarcomas of the uterus, we examined the distribution of marital status among 1479 white women diagnosed as having one of these tumors between January 1, 1973, and December 31, 1986, in 7 geographically defined areas of the United States. We estimated incidence rates based on the distribution of marital status of the female population of these seven areas as of 1980; adjustment for the prevalence of intact uteri in the estimated population-at-risk was performed using data from a survey of a representative sample of the United States population in 1982-1984. The incidence of uterine sarcoma was higher among never-married compared to ever-married women (rate ratio, 1.5; 95% confidence intervals, 1.3, 1.8). The association with marital status was similar for each of the three major histological categories (leiomyosarcomas, malignant mixed müllerian tumors, and endometrial stromal sarcomas). These results provide evidence that one or more characteristics associated with a woman's marital status may play a role in the etiology of one or more histological types of uterine sarcoma.
为了进一步探究子宫肉瘤的描述性流行病学，我们调查了1973年1月1日至1986年12月31日期间，在美国7个地理区域被诊断患有这些肿瘤之一的1479名白人女性的婚姻状况分布。我们根据1980年这七个地区女性人口的婚姻状况分布估计发病率；利用1982 - 1984年美国人口代表性样本调查的数据，对估计的风险人群中完整子宫的患病率进行了调整。与已婚女性相比，未婚女性子宫肉瘤的发病率更高（率比为1.5；95%置信区间为1.3, 1.8）。在三种主要组织学类型（平滑肌肉瘤、恶性混合苗勒管肿瘤和子宫内膜间质肉瘤）中，与婚姻状况的关联相似。这些结果表明，与女性婚姻状况相关的一个或多个特征可能在一种或多种组织学类型的子宫肉瘤病因中起作用。
