INSERM UMR S 945, Infections and Immunity, Université Pierre et Marie Curie-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France.
Immunol Lett. 2013 Jan;149(1-2):119-22. doi: 10.1016/j.imlet.2012.10.002. Epub 2012 Oct 13.
The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8(+) T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8(+) T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope.
决定 HLA-B27 限制性 HIV-1 p24 Gag 衍生 KK10 表位的免疫优势、疗效和几乎无处不在的 CD8(+) T 细胞反应的因素仍有待充分阐明。在这里，我们表明，与其他特异性相比，幼稚池中 KK10 反应性 CD8(+) T 细胞的前体频率或初始能力没有显著差异。这些数据暗示了 CD8(+) T 细胞对该表位的相对保护作用所涉及的替代机制。
