Hristova Maria, Dourmishev Lyubomir, Kamenarska Zornitsa, Kaneva Radka, Vinkov Anton, Mitev Vanio
Department of Clinical Laboratory and Clinical Immunology, Sofia Medical University, 28th Diagnostic and Consultative Center, Sofia, Bulgaria.
Acta Dermatovenerol Croat. 2012;20(3):148-56.
TNF-α and IL-10 single nucleotide polymorphisms have been implicated in various autoimmune diseases but the results are still quite controversial. This case-control study aimed to investigate the association between six TNF-α and five IL-10 polymorphisms with dermatomyositis. The -857CC and +489GG genotypes showed a weak association with dermatomyositis when the analysis was carried out for the whole cohort but they appeared to be a significant risk factor for the development of dermatomyositis in women. The TNF-α -1031CC genotype was found only among dermatomyositis patients. The TNF-α -1031C/-863C/-857C-308G/+489G haplotype showed a significant association with dermatomyositis in women. The IL-10 -3575TT genotype and T allele showed an association with dermatomyositis. The frequency of the IL-10 -2763CC genotype and C allele was higher among dermatomyositis patents and it was associated with an increased OR. Haplotype analysis showed an association between the IL-10 -3575T/-2763C haplotype and dermatomyositis. In conclusion, our results indicate that both TNF-α and IL-10 polymorphisms are associated with the development of dermatomyositis in Bulgarian patients.
肿瘤坏死因子-α（TNF-α）和白细胞介素-10（IL-10）单核苷酸多态性与多种自身免疫性疾病有关，但结果仍颇具争议。本病例对照研究旨在调查6种TNF-α多态性和5种IL-10多态性与皮肌炎之间的关联。对整个队列进行分析时，-857CC和+489GG基因型与皮肌炎呈弱关联，但它们似乎是女性患皮肌炎的一个重要危险因素。仅在皮肌炎患者中发现了TNF-α -1031CC基因型。TNF-α -1031C/-863C/-857C-308G/+489G单倍型与女性皮肌炎显著相关。IL-10 -3575TT基因型和T等位基因与皮肌炎有关联。皮肌炎患者中IL-10 -2763CC基因型和C等位基因的频率较高，且与比值比（OR）增加有关。单倍型分析显示IL-10 -3575T/-2763C单倍型与皮肌炎有关联。总之，我们的结果表明，TNF-α和IL-10多态性均与保加利亚患者皮肌炎的发生有关。
