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Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.

作者信息

Trudeau Matthew C

出版信息

J Gen Physiol. 2012 Nov;140(5):457-61. doi: 10.1085/jgp.201210898. Epub 2012 Oct 15.

DOI:10.1085/jgp.201210898
PMID:23071267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3483117/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/3483117/ddab3f752539/JGP_201210898R_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/3483117/ddab3f752539/JGP_201210898R_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81eb/3483117/ddab3f752539/JGP_201210898R_Fig1.jpg

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本文引用的文献

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Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.门控锁定 HCN 通道中的电荷运动揭示了电压传感器和门之间的弱耦合。
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2
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J Gen Physiol. 2012 Sep;140(3):279-91. doi: 10.1085/jgp.201210838.
3
A single charged voltage sensor is capable of gating the Shaker K+ channel.单个带电电压传感器能够控制Shaker钾通道。
J Gen Physiol. 2012 Dec;140(6):581-2. doi: 10.1085/jgp.201210928.
J Gen Physiol. 2009 May;133(5):467-83. doi: 10.1085/jgp.200810082.
4
Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination.通过二硫键桥联和Cd2+配位探究哺乳动物超极化激活的HCN通道中S4和S5段的接近程度
Pflugers Arch. 2009 Jun;458(2):259-72. doi: 10.1007/s00424-008-0613-3. Epub 2008 Nov 26.
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Closing in on the resting state of the Shaker K(+) channel.接近Shaker钾离子通道的静息状态。
Neuron. 2007 Oct 4;56(1):124-40. doi: 10.1016/j.neuron.2007.09.023.
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Kinetic relationship between the voltage sensor and the activation gate in spHCN channels.spHCN通道中电压传感器与激活门之间的动力学关系。
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