Scientific Computing Core Facility, Campus Science Support Facilities, 1030 Vienna, Austria.
Bioinformatics. 2012 Dec 15;28(24):3318-9. doi: 10.1093/bioinformatics/bts607. Epub 2012 Oct 15.
We present the MULTOVL application suite that detects and statistically analyses multiple overlaps of genomic regions in a fast and efficient manner. The package supports the detection of multiple region intersections, unions and 'solitary' genomic regions. The significance of actually observed overlaps is estimated by comparing them with empirical null distributions generated by random shuffling of the input regions.
我们介绍了 MULTOVL 应用程序套件，它能够快速有效地检测和统计分析基因组区域的多个重叠。该软件包支持检测多个区域的交集、并集和“孤立”的基因组区域。通过将输入区域随机打乱生成的经验性零分布来估计实际观察到的重叠的显著性。
