Koul Roshan, Al-Yahmedy Mohammed, Al-Futaisi Amna
Department of Child Health, Neurology Division, Sultan Qaboos University Hospital, Sultanate of Oman.
Oman Med J. 2012 Jul;27(4):310-3. doi: 10.5001/omj.2012.76.
A prospective study was designed to analyze risk factors and clinical features in children with global developmental delay (GDD) at our hospital. No previous data is available on GDD from Oman.
This study was conducted at Sultan Qaboos University Hospital from January 2008 until June 2009. All the children aged 5 years or less, referred with suspected GDD were included in the study. Data was analyzed to determine the underlying etiology. The children with neurodegenerative disease and muscular dystrophy were excluded from the study.
One hundred and ten children, 59 males (53.6%) and 51 females (46.4%) were included in the study. The mean age at initial evaluation was 13.29 months. An underlying etiology was determined in 79 (71.8%) children. Perinatal history was associated with significant difference in detection of etiology (p=0.039). Abnormal neurological examination was a significant factor in detection of the underlying etiology. Magnetic resonance imaging (MRI) in 105 children and metabolic screening in 93 children were the most frequently ordered investigations. Abnormal imaging, MRI (p=0.001), CT scan (p=0.036) and metabolic screening (p=0.034) were significantly associated with detection of etiology.
Etiology was detected in 71.8% of the children. MRI was the most significant investigation to detect the abnormality.
本前瞻性研究旨在分析我院全球发育迟缓（GDD）儿童的危险因素和临床特征。阿曼此前尚无关于GDD的相关数据。
本研究于2008年1月至2009年6月在苏丹卡布斯大学医院进行。所有5岁及以下疑似GDD的转诊儿童均纳入研究。对数据进行分析以确定潜在病因。患有神经退行性疾病和肌肉萎缩症的儿童被排除在研究之外。
110名儿童纳入研究，其中59名男性（53.6%），51名女性（46.4%）。初次评估时的平均年龄为13.29个月。79名（71.8%）儿童确定了潜在病因。围产期病史与病因检测的显著差异相关（p=0.039）。神经系统检查异常是检测潜在病因的重要因素。105名儿童进行了磁共振成像（MRI）检查，93名儿童进行了代谢筛查，这是最常进行的检查。影像学异常，MRI（p=0.001）、CT扫描（p=0.036）和代谢筛查（p=0.034）与病因检测显著相关。
71.8%的儿童检测到病因。MRI是检测异常的最重要检查。
