Friedman-Birnbaum R, Weltfriend S, Katz I
Department of Dermatology, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Dermatologica. 1990;180(1):13-7. doi: 10.1159/000247978.
The records of 67 Israeli patients with classical Kaposi's sarcoma treated at Rambam Medical Center were analyzed retrospectively for clinical and laboratory data. As expected, all except 1 patient were of Jewish origin. There was a male predominance with a ratio of 2.2:1. The age of onset was mostly during the 5th to 7th decades of life. The course of the disease was usually slow and indolent. As has been already noted, we found a higher frequency of diabetes mellitus (16.4%). Although a high frequency of second primary malignancy was seen in our patients, this was less so than that described in an American series, 15% as compared to 37%, respectively. The most frequent second malignancy was that of the lymphoreticular system. No serologic evidence for an association with types of herpes virus infection has been found. No alterations in humoral and cellular immunity were demonstrated. These data show similar clinical findings with those described in other series, besides the lower frequency of a second primary malignancy. Some discordance with that described before concerning the relationship with cytomegalovirus infection and T cells subsets was also noted.
对在兰巴姆医疗中心接受治疗的67例以色列经典型卡波西肉瘤患者的记录进行回顾性分析，以获取临床和实验室数据。不出所料，除1例患者外，所有患者均为犹太裔。男性占主导，男女比例为2.2:1。发病年龄大多在50至70岁之间。疾病进程通常缓慢且隐匿。正如已经指出的，我们发现糖尿病的发生率较高（16.4%）。尽管在我们的患者中发现第二原发性恶性肿瘤的发生率较高，但低于美国系列报道的发生率，分别为15%和37%。最常见的第二原发性恶性肿瘤是淋巴网状系统肿瘤。未发现与疱疹病毒感染类型相关的血清学证据。未显示体液免疫和细胞免疫有改变。这些数据显示出与其他系列报道相似的临床发现，只是第二原发性恶性肿瘤的发生率较低。还注意到与之前描述的关于巨细胞病毒感染和T细胞亚群关系存在一些不一致。
