Palma Miguel, Borja-Santos Nuno, Trancas Bruno, Klut Catarina, Cardoso Graça
Hospital Professor Doutor Fernando Fonseca, EPE, Amadora, Portugal.
Innov Clin Neurosci. 2012 Sep;9(9):18-20.
The role of cerebellar pathology in psychiatric symptoms has long been recognized. Cerebellar pathology has been associated with obsessive-compulsive disorder pathophysiology, particularly with compulsive hoarding. Likewise, some cerebellum abnormalities have been described in schizophrenia, as well as in comorbidity between obsessive-compulsive disorder and schizophrenia. The authors report the case of a 32-year-old woman with obsessive-compulsive disorder and a cerebellum development variant in a family with a strong schizophrenia loading. This case emphasizes the probable role of the cerebellum in the pathophysiology of both obsessive-compulsive disorder and schizophrenia, and reconsiders the existence of a so called schizo-obsessive subtype of schizophrenia.
小脑病变在精神症状中的作用早已得到认可。小脑病变与强迫症的病理生理学有关，尤其是与强迫性囤积行为相关。同样，在精神分裂症以及强迫症与精神分裂症的共病中也描述了一些小脑异常情况。作者报告了一例32岁患有强迫症且小脑发育变异的女性病例，其家族有很强的精神分裂症遗传倾向。该病例强调了小脑在强迫症和精神分裂症病理生理学中可能发挥的作用，并重新审视了所谓精神分裂症-强迫症亚型的存在。
