Estée Lauder Companies, Biological Research Department, Oevel, Belgium.
Int J Cosmet Sci. 2013 Apr;35(2):149-55. doi: 10.1111/ics.12016. Epub 2012 Nov 29.
Solar lentigines are benign hyperpigmented skin lesions. Despite their widespread distribution, knowledge on the mechanisms of development is largely unknown. A clinical study was designed in which solar lentigines were characterized using various non-invasive clinical techniques. A subset of solar lentigines was followed over a 5-year time period. One hundred and twenty-eight solar lentigines were evaluated using in vivo reflectance confocal microscopy (RCM) for the evaluation of the length and density of their dermal papillae as well as the deformation of the alignment pattern of hyperrefractive basal cells. Skin colour, colour contrast, the size of the solar lentigo, epidermal proliferation rate, melanin and haemoglobin content were quantified. RCM imaging of solar lentigines revealed a profound structural deformation of the dermal papillae, as the alignment pattern of hyperrefractive basal cells shifted from a circle in non-lesional skin to an irregular non-circular shape in solar lentigines. There was a rise in the number of dermal papillae, and these dermal papillae were significantly longer. Solar lentigines had increased melanin and haemoglobin levels and a higher rate of epidermal proliferation. For a subset of nineteen solar lentigines, a longitudinal study was set-up in which these measurements were repeated 5 years after the first evaluation. The deformation and the number of the hyperrefractive dermal papillary rings increased significantly over the 5-year time span. The size of the lesion increased, and the skin colour became darker. RCM is a useful non-invasive clinical tool for the characterization of solar lentigines, in particular the compressive deformation of the dermal papillae. This deformation became more severe over a time period of 5 years. To our knowledge, this is the first time that the in vivo time-dependent progression of solar lentigines was supported by RCM images, contributing to an improved understanding of the formation and progression of solar lentigines.
日光性雀斑样痣是良性的色素沉着性皮肤病变。尽管其分布广泛，但对其发病机制的了解还很有限。本研究采用各种非侵入性临床技术对日光性雀斑样痣进行了特征描述，并对其中一部分患者进行了为期 5 年的随访。采用共聚焦激光扫描显微镜（RCM）对 128 例日光性雀斑样痣进行评估，以评估其真皮乳头的长度和密度以及高折光性基底细胞的排列模式的变形。对皮肤颜色、颜色对比度、日光性雀斑样痣的大小、表皮增殖率、黑色素和血红蛋白含量进行了量化。RCM 成像显示，日光性雀斑样痣的真皮乳头结构发生了明显的变形，高折光性基底细胞的排列模式从非病变皮肤的圆形变为不规则的非圆形。真皮乳头数量增加，且明显变长。日光性雀斑样痣的黑色素和血红蛋白含量增加，表皮增殖率也增加。对其中 19 例日光性雀斑样痣进行了纵向研究，在首次评估 5 年后重复了这些测量。5 年期间，高折光性真皮乳头环的变形和数量显著增加。病变的大小增加，皮肤颜色变深。RCM 是一种有用的非侵入性临床工具，可用于日光性雀斑样痣的特征描述，特别是真皮乳头的压缩变形。这种变形在 5 年内变得更加严重。据我们所知，这是首次通过 RCM 图像来支持日光性雀斑样痣的体内时程进展，有助于更好地理解日光性雀斑样痣的形成和进展。
