Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, 463-707, Gyeonggi-do, Republic of Korea.
BMC Gastroenterol. 2012 Oct 18;12:145. doi: 10.1186/1471-230X-12-145.
Liver function tests (LFTs) can be affected by many factors and the proposed effects of coffee on LFT require a comprehensive evaluation. The aim of this study was to elucidate whether drinking coffee, smoking, or drinking alcohol have independent effects on LFTs in Korean health-check examinees.
We used the responses of 500 health-check examinees, who had participated in a self-administered questionnaire survey about coffee, alcohol drinking, and smoking habits.
Coffee consumption was closely related to male gender, high body mass index (BMI), alcohol drinking, and smoking. On univariable and multivariable analyses, drinking coffee lowered serum levels of total protein, albumin, and aspartate aminotransferases (AST). On multivariable analyses, smoking raised serum γ-glutamyl transferase (GGT) level and decreased serum protein and albumin levels, while alcohol drinking raised GGT level after adjustment for age, gender, regular medication, BMI, coffee and alcohol drinking amounts, and smoking.
Coffee consumption, smoking, and alcohol drinking affect the individual components of LFT in different ways, and the above 3 habits each have an impact on LFTs. Therefore, their effects on LFTs should be carefully interpreted, and further study on the mechanism of the effects is warranted.
肝功能检查（LFT）会受到许多因素的影响，咖啡对 LFT 的影响需要进行全面评估。本研究旨在阐明在韩国健康检查受检者中，喝咖啡、吸烟或饮酒是否对 LFT 有独立影响。
我们使用了 500 名健康检查受检者对咖啡、饮酒和吸烟习惯的自我管理问卷调查的回答。
咖啡的摄入与男性、高体重指数（BMI）、饮酒和吸烟密切相关。在单变量和多变量分析中，喝咖啡会降低血清总蛋白、白蛋白和天门冬氨酸氨基转移酶（AST）水平。在多变量分析中，吸烟会升高血清γ-谷氨酰转移酶（GGT）水平，降低血清蛋白和白蛋白水平，而饮酒会在调整年龄、性别、常规用药、BMI、咖啡和酒精摄入量以及吸烟状况后升高 GGT 水平。
咖啡的摄入、吸烟和饮酒以不同的方式影响 LFT 的各个组成部分，这 3 种习惯都会对 LFT 产生影响。因此，应该仔细解释它们对 LFT 的影响，并且有必要对其作用机制进行进一步研究。
