Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.
Dement Geriatr Cogn Disord. 2012;34(3-4):190-7. doi: 10.1159/000343075. Epub 2012 Oct 15.
We investigated whether neurotrophin (NT)-3 polymorphisms influenced the executive function of patients with 2 separate disease stages with similar dementia conditions: amnestic mild cognitive impairment (A-MCI) or mild Alzheimer disease (AD).
Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630. Next, we compared the frontal assessment battery (FAB) total and subtest scores between the three genotypic groups.
The total FAB score was not significantly associated with the rs6332 and rs6489630 genotypes; however, the conflicting instructions score among the 6 subtests was significantly associated with the rs6332 genotype (p < 0.05). Moreover, in patients with mild AD, the conflicting instructions score differed significantly among the three genotypic groups of rs6332 (p < 0.05) (G/G < A/A: p = 0.042 and G/A < A/A: p = 0.041). No significant differences in any other demographic variables were observed among the three genotypes of rs6332 and rs6489630.
These results suggested that an NT-3 polymorphism, rs6332, may significantly influence executive function, reflecting interference performances among patients with mild-stage AD.
我们研究了神经营养因子 (NT)-3 多态性是否会影响具有相似痴呆症的 2 种不同疾病阶段的患者的执行功能：遗忘型轻度认知障碍 (A-MCI) 或轻度阿尔茨海默病 (AD)。
在 215 名痴呆症和 MCI 的门诊患者中，招募了 155 名轻度 AD (n = 108) 或 A-MCI (n = 47) 患者，并根据代表性的 NT-3 功能多态性 rs6332 和 rs6489630 将其分为 3 种基因型组。然后，我们比较了 3 种基因型组之间的额叶评估量表 (FAB) 总分和子测试分数。
FAB 总分与 rs6332 和 rs6489630 基因型无显著相关性；然而，6 个子测试中的冲突指令评分与 rs6332 基因型显著相关 (p < 0.05)。此外，在轻度 AD 患者中，rs6332 三种基因型之间的冲突指令评分差异显著 (p < 0.05) (G/G < A/A：p = 0.042 和 G/A < A/A：p = 0.041)。在 rs6332 和 rs6489630 的三种基因型中，未观察到任何其他人口统计学变量的显著差异。
这些结果表明，NT-3 多态性 rs6332 可能显著影响执行功能，反映了轻度 AD 患者的干扰表现。
